KCNA1 and episodic ataxia type 1: However, the observed increase in neuronal excitability predicted by our models and the increased firing rates and decreased rheobases observed with KV1.1 channel block in sensory neurons (78), as well as clinical data reflecting positive outcomes of SCBs in EA1 patients (Table 1; Figure 2) provide a rational basis for the suggestion of the use of SCBs in EA1.