In the context of dilated cardiomyopathy (DCM), the point mutation at R158 could influence telethonin phosphorylation at S161, as the kinases PKD and CaMKII exhibit a preference for arginine at position −3 of the phospho-acceptor residue (Nishikawa et al., 1997; Swulius and Waxham, 2008). The gene discussed is PRKD1; the disease is familial dilated cardiomyopathy.