For instance, ETb blockade accelerated cyst growth in a Pkd2WS25/− orthologous mouse model of ADPKD (obtained by intercrossing Pkd2+/− and Pkd2WS25/WS25 founder mice), while simultaneous blocking of ETa neutralized this effect (Chang et al., 2007). This evidence concerns the gene EDNRA and autosomal dominant polycystic kidney disease.