Reduced food intake also decreased serum glucose level and ameliorated ADPKD progression in PKDcond/cond: NesCre (Kipp et al., 2016) and Pkd1RC/RC (Warner et al., 2016) mouse models, and the mechanisms were, respectively, reported to be mediated by activation of the AMPK pathway, which is a negative regulator of mTOR (Rowe et al., 2013; Kipp et al., 2016; Riwanto et al., 2016; Warner et al., 2016). Here, MTOR is linked to autosomal dominant polycystic kidney disease.