PKD1 and autosomal dominant polycystic kidney disease: Dietary interventions, such as fasting and ketogenic diets, which downregulate aerobic glycolysis because of low glucose availability, ameliorated cyst growth in an orthologous mouse model of ADPKD with a mosaic conditional knockout of Pkd1 (Kipp et al., 2016), in Pkd1RC/RC and Pkd2WS25/- mice (Warner et al., 2016), and in rat (Han:SPRD Cy/+), mouse (Pkd1cond/cond:Nescre), and feline models of PKD (Torres et al., 2019).