This process is known as a shift from OXPHOS to aerobic glycolysis or the “Warburg effect”; a similar shift from OXPHOS to glycolysis was discovered in Pkd1−/− mouse embryonic fibroblasts (MEFs), kidneys from humans with ADPKD (Rowe et al., 2013), and murine models of ADPKD (Rowe et al., 2013; Chiaravalli et al., 2016; Riwanto et al., 2016). This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.