Specific liver-knockout of PTP1B protected mice from chronic alcohol plus binge-induced oxidative stress, liver fibrosis and inflammation via the inhibition of nuclear factor kappa B (NF-κB) and reduction of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) and NOX4 expression (Hsu et al., 2020). The gene discussed is PTPN1; the disease is Hepatic fibrosis.