ANXA2 and venous thromboembolism: In humans, an increased annexin A2 expression in acute promyelocytic leukemia (APL) is associated with hyperfibrinolysis and bleeding (Menell et al., 1999; Liu et al. 2011) while reduced annexin A2 expression impairs cell surface fibrinolysis and may constitute a risk factor for venous thromboembolism (Fassel et al., 2021).