ANXA5 and neoplasm: Because of its high affinity binding to PS exposed on the membrane of apoptotic cells, various annexin A5 imaging probes have been used and found to be safe in human imaging studies (Boersma et al., 2005), including cardiovascular disease (Thimister et al., 2003; Korngold et al., 2008), allograft rejection in transplants (Blankenberg et al., 2000; Kown et al., 2001; Narula et al., 2001), and evaluation of cancer treatment efficacy by assessing apoptosis of tumor cells after treatment (Belhocine et al., 2002; Mochizuki et al., 2003; Kartachova et al., 2004).