ANXA5 and serum lipopolysaccharide activity: Besides beneficial results shown in heart tissue in endotoxemia, annexin A5 treatment also improved tissue damage and function in the liver (Park et al., 2016), and gut (Beattie et al., 2019) in similar conditions, with anti-inflammatory effects reducing endothelial damage, and protective effects against sepsis induced coagulopathy by preventing fibrin deposition in organ microvasculature (Beattie et al., 2019).