Inhibits MAPK, Akt, and NK-κB activation in endotoxemia; inhibits TNF-α and IL-1β expression in endotoxemia, improves cardiac function in endotoxemia, improves animal survival in endotoxemia, inhibits LPS-binding to TLR4/MD-2 fusion protein. Here, LY96 is linked to serum lipopolysaccharide activity.