Various annexin A5 imaging probes have been found to be safe in human imaging studies in vivo (Boersma et al., 2005), and have been used to image apoptosis in various conditions, including cardiovascular disease (Thimister et al., 2003; Korngold et al., 2008), allograft rejection in transplants (Blankenberg et al., 2000; Kown et al., 2001; Narula et al., 2001), evaluation of cancer treatment efficacy by assessing apoptosis of tumor cells after treatment (Belhocine et al., 2002; Mochizuki et al., 2003; Kartachova et al., 2004). This evidence concerns the gene ANXA5 and neoplasm.