Annexin A1 analogue Ac2-26 and recombinant human annexin A5, which have been shown in animal models of sepsis and other inflammatory models to reduce expression of pro-inflammatory cytokines, possess anticoagulant properties via inhibition of thrombin generation and platelet aggregation, and modulate the response to apoptosis, are promising therapeutic agents to reduce the severity of inflammatory processes in COVID-19. This evidence concerns the gene ANXA1 and Sepsis.