ANXA5 and Sepsis: Annexin A5 and its human recombinant homodimer, diannexin, which was designed to have a longer circulating half time and greater binding affinity (Rand et al., 2012b), has been explored as a therapeutic protein in a wide range of disease conditions and contexts, most notably inflammation, sepsis, hemorrhage, coagulopathy, ischemia, and organ transplant.