Another study indicates that inhibition of NF-κB inflammatory cascade using JSH-23 reversed the functional, sensorimotor and biochemical deficits by decreasing neuroinflammation (IL-6, TNF-α, COX-2 and iNOS) and improving antioxidant defence (Nrf2 and HO-1) in diabetic neuropathy (Kumar et al., 2011). Here, HMOX1 is linked to diabetic neuropathy.