It is demonstrated that NQO1 expression is the activation of aryl hydrocarbon receptor (AhR) pathway by propolis, which promotes lung repair in a mouse emphysema model caused by CS exposure (Barroso et al., 2017).Also, studies have proved that NQO1 P187S polymorphisms is determined as risk genotype in children with obstructive bronchitis, whose mother smoke actively during their pregnancies. The gene discussed is NQO1; the disease is pulmonary emphysema.