Given that Nqo1-AS1 human homologue is positively correlated with Nqo1 mRNA expression in PBMCs of patients with COPD, we speculated that Nqo1-AS1 might also be positively associated with Nqo1 mRNA expression in lung tissue of mice exposed to cigarette smoke. The gene discussed is NQO1; the disease is chronic obstructive pulmonary disease.