INS and hydrops fetalis: Female obese mice showed doubled plasma insulin levels after 5 months of a HF or HF + HS diet compared to female CD-fed mice (female: CD = 0.57 ± 0.08; HF = 1.18 ± 0.01*; HF + HS = 1.23 ± 0.19* ng/ml; n = 3–4/group; *p < 0.05 vs. CD).