However, results from successive trials (Giamarellos-Bourboulis et al., 2016) and systematic meta-analyses (Cui et al., 2019) indicate that intravenous IgM-enriched immunoglobulins reduced mortality (Cui et al., 2019) and the addition of IgM enriched solution to the SSC bundles appears as a promising treatment option, in particular in those patients with an acute disease onset, who are heavily inflamed, showing signs of overt septic shock and those with an immunocompromised phenotype, (patients in an immunosuppressive stage) (Nydegger and Sturzenegger, 1999; Nierhaus et al., 2020). The gene discussed is CD40LG; the disease is septic shock.