The thrombin receptors, protease-activated receptors (PAR) 1 and 2 (Kallis et al., 2014; Nault et al., 2016; Shearer et al., 2016), and the bradykinin receptor, beta 2 (BDKRB2), are upregulated in liver fibrosis with a possible involvement of the latter and its ligand, bradykinin (BK) in fibrotic resolution (Sancho-Bru et al., 2007). The gene discussed is KNG1; the disease is Hepatic fibrosis.