Waniczek et al. (2017) suggested that intense M2 macrophages (CD68 + iNOS-) infiltration within the tumor stroma was associated with shorter disease-free survival (DFS) and OS. In contrast, intense infiltration at the tumor edge and the surrounding tissues was associated with a lower recurrence rate (Waniczek et al., 2017). In resected colorectal liver metastases stained for CD68, a high density of TAMs correlated with longer DFS (Cavnar et al., 2017). Here, CD68 is linked to neoplasm.