The inflammatory factors including TNF-α, IL-6 were increased significantly after sepsis, Mdivi-1 distinctly reduced the levels of TNF-α, IL-6 in serum, myocardial tissue, and vascular smooth muscle tissue (Figures 5E,F), and the phosphorylation of NF-κ B p65 in myocardial tissue and vascular smooth muscle tissue (Figures 5A,C). The gene discussed is TNF; the disease is Sepsis.