While confirming previous data from our and other’s laboratory (Shishikura et al., 2016; Totani et al., 2016), the present results provide the novel observation that PDE4 blockade is more efficient at reducing NETs under CF conditions, suggesting that impairment of CFTR function induces signaling events that favor the activity of the PDE4 inhibitor. This evidence concerns the gene PDE4A and cystic fibrosis.