Correlation analyses between inflammation markers and the body weight loss at 5 days after infection, including all animals treated with roflumilast or a vehicle of both experimental protocols (per os or intratracheal) (Supplementary Figure S3), showed that the number of neutrophils (A) as well as the amount of free DNA (B), KC (D), and total proteins (F) in the BALF, positively correlated with the weight loss. Here, CALCA is linked to infection.