NFE2L2 and cancer: While NRF2 activators provide beneficial therapeutic effects in a variety of stress-related diseases (Cuadrado et al., 2019), aberrant NRF2 activation is often observed in many types of tumors and is closely correlated with poor prognosis because NRF2 activation confers significant advantages towards the growth, proliferation, and metastasis of cancer (Rojo De La Vega et al., 2018).