Experimental findings obtained from female AD mouse models (5xFAD; Familial AD) expressing either ApoE3 or ApoE4 mice that were exposed to urban nano PM for 15 weeks showed increased Aβ plaques and soluble Aβ oligomers, which were associated with neuronal changes in the hippocampus (Cacciottolo et al., 2017). The gene discussed is APOE; the disease is Alzheimer disease.