Comparing “younger” and “older” MS groups, significant differences were found in IL-8 [“younger” median (IQR) = 18.62 (13.67–25.02); “older” median (IQR) = 23.41 (15.47–30.78); p = 0.003, B–H adjusted p = 0.033] and MCP-1/CCL2 [“younger” median (IQR) = 109.71 (85.79–143.43); “older” median (IQR) = 143.72 (102.55–179.89); p < 0.001, B–H adjusted p < 0.01] CSF levels. Here, CXCL8 is linked to myeloid sarcoma.