In animal models of PD, VIP Prevents oxidative stress and apoptosis in 6-hydroxydopamine (6-OHDA)-lesioned rats (Tuncel et al., 2012) and PACAP improves learning and memory in three different paradigms of the water-maze task in MPTP-injected mice (Onoue et al., 2002). Here, ADCYAP1 is linked to Parkinson disease.