INS and obesity due to melanocortin 4 receptor deficiency: The 1998 Quebec ice storm was a powerful enough stressor that high scores on the maternal objective hardship scale predicted a full standard deviation lower IQ in the children at age 2 (Laplante et al., 2004) and again at 5 1/2 years (Laplante et al., 2008), higher body mass index and obesity rates at ages 5 1/2 (Dancause et al., 2012) through age 15 (Liu et al., 2016), and higher insulin secretion (Dancause et al., 2013) and pro-inflammatory cytokines (Veru et al., 2015) at age 13.