Recently, intravitreal injection of transferrin, a natural Fe chelator, has been demonstrated to have neuroprotective effects against oxidative stress in retinal degeneration: after injection in the vitreous, transferrin spans rapidly within the retina and accumulates in photoreceptors and in RPE, protecting retinal function from loosely bound Fe (Picard et al., 2015). This evidence concerns the gene TF and retinal degeneration.