High levels of ceruloplasmin and the activation of the ceruloplasmin:transferrin (Cp:Tf) system, one of the main antioxidant systems acting in general circulation, were associated with worse cognitive performances and a severe medial temporal lobe atrophy, supporting the view that local iron accumulation in brain areas critical for AD might be strictly associated with Fe systemic alterations (Squitti et al., 2010). This evidence concerns the gene CP and Alzheimer disease.