TF and Alzheimer disease: High levels of ceruloplasmin and the activation of the ceruloplasmin:transferrin (Cp:Tf) system, one of the main antioxidant systems acting in general circulation, were associated with worse cognitive performances and a severe medial temporal lobe atrophy, supporting the view that local iron accumulation in brain areas critical for AD might be strictly associated with Fe systemic alterations (Squitti et al., 2010).