In addition to Aβ, several protein and lipid constituents of drusens – including clusterin, vitronectin, amyloid P, esterified cholesterol and phosphatidylcholine, apolipoprotein E, and inflammatory mediators, such as acute phase reactants and complement components (C5, C5b9, and C3 fragments) – are also present in insoluble cerebral aggregates of AD (Mullins et al., 2000; Crabb et al., 2002; Luibl et al., 2006; Isas et al., 2010; Wang et al., 2010). Here, APOE is linked to Alzheimer disease.