An imbalance between the NGF-dependent, TrkA-mediated survival, the growth actions, and the p75NTR-mediated activation of apoptosis/growth inhibitory pathway is causally associated with the onset and/or development of several neurodegenerative diseases of both CNS and PNS (Micera et al., 2004; Cuello et al., 2007, 2010; Garcia et al., 2017), including AD (Sofroniew et al., 2001; Schulte-Herbruggen et al., 2008; Cattaneo and Calissano, 2012) and AMD (Lambiase et al., 2009; Telegina et al., 2019; Esposito et al., 2021). The gene discussed is NGF; the disease is Alzheimer disease.