MFSD2A and neurodegenerative disease: An intact BBB severely restricts drug delivery to the CNS (Ben-Zvi et al., 2014), while Mfsd2a plays a key role in BBB permeability regulation and integrity maintenance by specifically inhibiting vesicle mediated transcytosis in BBB capillary endothelial cells, so the targeting of Mfsd2a might help promote effective drug delivery in the treatment of life-threatening CNS infections, neurodegenerative diseases and brain tumors.