A study published in 2020 has shown that LncRNA-CASC7 enhances corticosteroid sensitivity through miR-21 by inhibiting the PI3K/AKT pathway and highlighted a potential therapeutic option in severe asthma, and it may also serve as a predictor of inhaled corticosteroid treatment response over time in asthma [141]. The gene discussed is AGO2; the disease is asthma.