Activation of the Notch gene is crucial for Th2 response in asthma, and Notch 1 dysregulated signaling of T cells is observed through the hyperacetylation of H3K9, H3K14, H3K18, H3K27, and H3K16 and trimethylation of H3K4 and H3K79 [88]. Here, NOTCH1 is linked to asthma.