Hypermethylated GATA3 (location 10p14), a significant regulator of Th2 differentiation, is associated with reduced asthma risk in cord blood [40], while ZPBP2 (Zona Pellucida Binding Protein 2) hypomethylation results in asthma in a lymphoblastoid cell line at genetic location 17q12-q21 [41]. The gene discussed is GATA3; the disease is asthma.