Based on experimental evidence, low levels of neuroactive peptides, such as VGF and BDNF, may contribute to memory and cognitive impairments, whereas decreased levels of CysC and the prohormone convertase-binding proteins 7B2 and proSAAS could promote amyloidogenesis [34, 66, 67, 79, 80]. This evidence concerns the gene PCSK1N and Cognitive impairment.