Since the report of striking amounts of CgA in AD dystrophic neurites, almost every DCV marker has been detected as accumulating in these degenerative structures, including transmitter cargos (e.g. BDNF) and intrinsic molecular machinery (i.e. granin family members) but not SV components [22, 45, 50, 54, 65–67]. Here, BDNF is linked to Alzheimer disease.