SOCS3 and type 2 diabetes mellitus: In the present study, we investigated the independent and combined effects of progesterone and SOCS3 methylation on T2DM among men and postmenopausal women in Henan rural areas, and discovered that progesterone was associated with an increased risk of T2DM; nevertheless, methylation of Chr17:76356190 or Chr17:76356199 was associated with a decreased risk of T2DM.