SOCS3 and type 2 diabetes mellitus: Thus, using the data from the Henan Rural cohort, the present research aimed to (1) assess the associations of progesterone and methylation of Chr17:76356190 and Chr17:76356199 (SOCS3) with T2DM; and (2) further examine the combined effects of progesterone and SOCS3 methylation on T2DM.