Compared to individuals with high level of Chr17:76356190 or Chr17:76356199 (SOCS3) methylation and low levels of progesterone, those with low level of Chr17:76356190 or Chr17:76356199 (SOCS3) methylation and high levels of progesterone had a greater risk of prevalent T2DM. This evidence concerns the gene SOCS3 and type 2 diabetes mellitus.