11 of those 18 RNAs (WISP2, CXCL13, POSTN, COL5A2, COL13A1, COL18A1, OMD, CLEC11A, FBN1, SFRP1, SPOCK2) were either up-regulated in PAFs with high breast cancer expression of the human orthologues associated with poor prognosis, or down-regulated in PAFs with low breast cancer expression associated with poor prognosis, and therefore potential drivers of progression within the signature. The gene discussed is SPOCK2; the disease is breast cancer.