Comparisons of the clinical data in the two groups showed that pleural effusion, ascites, hydronephrosis, skin rash, lupus nephritis, leukopenia, hypoalbuminemia, hypocomplementemia (C3 and C4), increased IgA level, and positivity for anti-nucleosome-ANA antibodies were significantly more common in the LEn group (all P < 0.05; Table 2). This evidence concerns the gene BTG3 and Hypoalbuminemia.