Genes expressed in common between the 3 classes of malaria comprised those of inflammatory response (CKLF), ER stress (RNF13), detoxification of toxic metals and antioxidant response (MT1X), cellular stress (HSPs), clathrin and adaptor protein complex 2 assembly (PICALM) and mental retardation (AUTS2). The gene discussed is PICALM; the disease is Intellectual disability.