in their findings showed a down-regulation of pre-synaptic synuclein alpha (SNCA), hydroxyacylglutathione hydrolase (HAGH), ankyrin 1 (ANK1), ferro chelatase (FECH), STAT1, homolog A, nucleotide excision repair (RAD23A) and 2,3-bisphosphoglycerate mutase (BPGM) genes in CM patients [30]. The gene discussed is SNCA; the disease is cutaneous mastocytosis.