FZD7 and brain edema: Activation of FZD7 reduced brain edema and improved limb placement test compared to the ICH control group (p < 0.05; Fig. 3G, C) and FZD7 activation improved brain edema and neurological scores in Garcia and limb placement tests compared with FZD7 knockdown group 24 h post-ICH (p < 0.05; Fig. 3G, A, C).