Finally, they demonstrated that tumor-stromal cells axis plays a role not only in the bone marrow microenvironment but also in primary tumors where tumor-associated macrophages are the source of IL-6 among others and this was consistent with the observation of an abundant presence of LGALS3BP in primary human tumor specimens in proximity of IL-6 expressing cells [61]. The gene discussed is LGALS3BP; the disease is neoplasm.