Moreover, using LNCaP cell model researcher suggested that LGALS3BP induced IL-6 release which, in turn upregulated promatrilysin (pro-MMP-7), a matrix metalloproteinase responsible of degradation of many ECM (Extracellular Matrix) proteins and whose expression is crucial in prostate cancer [51]. The gene discussed is LGALS3BP; the disease is Familial prostate cancer.