To examine the link between neuronal TNFR1 and NF-κB signaling in CNS demyelinating disease, we crossed mice carrying a conditional floxed allele for IKKβ (IKKβff mice), the main NF-κB activating kinase in the canonical NF-κB pathway [22] with CamkII-Cre mice, to generate nIKKβKO mice [30]. Here, IKBKB is linked to demyelinating disease.