TNF and myeloid sarcoma: While the main effects of TNF in the CNS are undoubtedly mediated by non-neuronal cells including resident glia and infiltrating immune cells during disease, here we wanted to investigate the specific contributions of neuronal TNFR1 and TNFR2 to inflammatory and excitotoxic neurodegeneration processes relevant for MS, and to place these in the context of previous knowledge concerning neuroprotective effects of solTNF (and therefore TNFR1) in neuronal cultures in vitro [14, 15].