By analyzing the genomic, transcriptome and proteomic characteristics of 373 endometrial cancer patients, TCGA divided endometrial cancer into four subtypes, namely, POLE hyper-mutation, high-mutation microsatellite instability (MSI), high-copy number type (such as p53 gene mutation) and non-specific molecular variation (NSMP). The gene discussed is POLE; the disease is endometrial cancer.