To verify the role of ATM in the ALDOA-induced cell cycle progression, we transfected ATM siRNA into pancreatic cancer cells stably expressing ALDOA shRNA vector or scramble vector and found that transfection reduced the percentage of cells in G2/M phase in the ALDOA shRNA vector cells compared with the cells expressing scramble vector. The gene discussed is ALDOA; the disease is familial pancreatic carcinoma.