BSG and neoplasm: The tumor volume was significantly reduced in EMMPRIN shRNA transfected 143B cells as compared to the corresponding mock shRNA transfected 143B cells in vivo (5.3 ± 1.2 mm3 vs. 20.9 ± 3.9 mm3, p = 0.002) (Fig. 5A,B) The number of nodules was also reduced in EMMPRIN shRNA transfected cells (13.2 ± 2.00 vs. 27.0 ± 3.0, p = 0.001) (Fig. 5A,C).