Moreover, in other tumors such as hepatocellular carcinoma (HCC) [11], non-small-cell lung cancer (NSCLC) [12], esophageal squamous cell carcinoma (ESCC) [13] and gastric cancer (GC) [14], the down-regulation of BATF-2 expression is associated with a poor prognosis. Here, BATF2 is linked to esophageal squamous cell carcinoma.