Sheng et al. had proven that rising PLOD2 in both LSCC cell line Hep-2 and hypopharyngeal squamous cell carcinoma (HPSCC) cell line Fadu could promote stem-like characteristics in cancer through validating CD44/CD133 and has a significant connection to canonical Wnt signal pathway [42]. This evidence concerns the gene CD44 and hypopharynx squamous cell carcinoma.