Recently, bioinformatic analysis revealed the putative role of AP3B1 in amyotrophic lateral sclerosis pathogenesis, a neurodegenerative disease that affects muscle movement [188] Alveolar epithelial cells with defective AP3B1 were found to display abnormal mitochondrial formation [189], while lung tissues showed increased matrix metalloproteinase activity [190], suggesting a potential role of AP3B1 in lung tissue. The gene discussed is AP3B1; the disease is amyotrophic lateral sclerosis.