However, with or without AP2A1, AP2A2 aberrant expression is linked to Alzheimer’s disease [76,77,84–87] and is specifically linked to obesity [81,88], coronary disease [89], chronic bronchitis [90,91] and nicotine withdrawal [92], suggesting that α isoforms may have distinct roles in cells. Here, AP2A1 is linked to early-onset autosomal dominant Alzheimer disease.