Preclinical studies have revealed that vascular endothelial growth factor (VEGF) and vascular endothelial growth factor A (VEGF‐A) are detected in tumor lesions, and VEGF and VEGF‐A expression are positively correlated with pathological grade of bone sarcoma and negatively correlated with progression‐free survival (PFS). The gene discussed is VEGFA; the disease is bone sarcoma.