CASP3 and chronic myelogenous leukemia, BCR-ABL1 positive: Furthermore, the rapid and strong activation of caspase-3/7, induction of PARP cleavage, and that cell death could be blocked by zVAD, a pan-caspase inhibitor proved that the drug combination exerted its antitumorigenic effect mainly through the induction of apoptosis both in CML lines and primary CML stem/progenitor cells, although variable proportions of cells in the CML lines also showed characteristics of GSDME-dependent pyroptosis.