To test whether the observed anticlonogenic effect of S63845 on CD34+ CML cells is selective for the leukemic stem/progenitor cells, colony forming assays were also carried out on CD34+ stem/progenitor cells isolated from the bone marrow of four healthy donors (Fig. 8 and Supplementary Fig. 3B, right panels). The gene discussed is CD34; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.