TPO and chronic myelogenous leukemia, BCR-ABL1 positive: Next, we analyzed (in the presence of SCF, FL and TPO) the effects of the drugs on the expression of apoptotic and pyroptotic markers and key antiapoptotic members of the BCL2 and BIRC gene families in CD34+ stem/progenitor cells isolated from a CML patient at diagnosis by western blot (Fig. 7E).