TGFB1 and neoplasm: To functionally assess the potential anti-apoptotic role of RAC1B following TGFβ stimulation we generated organoids from VillinCreERT2Apcfl/flTP53fl/fl mice with or without RAC1B overexpression (Apcfl/flP53 or Apcfl/flP53 Rac1b) to model the early tumour-like lesions seen in the day-31 model.