As well, the endocrine system signalings (thyroid hormone signaling) and immunology signalings (platelet activation signal; Th1, Th2, and Th17 cells differentiation) were observed in infected hCD147 mice (Fig. 3a), which were also observed in COVID-19 patients.24–26 Then, we conducted trend analysis of the RNA-seq data to enrich genes with three different profiles, including profile 1 (continuously decreasing from 2 to 13 d.p.i.), profile 2 (reaching the plateau at 6 d.p.i.), and profile 3 (reaching the peak at 6 d.p.i.)(Fig. 3b). The gene discussed is TG; the disease is COVID-19.