As major therapeutic agents used in clinical practice, colchicine (Col), nonsteroidal anti-inflammatory drugs (NSAIDs), and corticosteroids inhibit NALP3 inflammasome-induced caspase-1 activation and IL-1β release caused by MSU crystals in gouty arthritis, as well as inhibit chemotactic factors released from neutrophil lysosomes [4]. Here, IL1B is linked to gout.