VEGFA and central nervous system cancer: While ES-CRiSP has been found to inhibit the proliferation of HUVEC and glioma human microvascular endothelial cells (gHMVEC), it has no effect on MAPKs including p38 kinase and stress-activated protein kinase (SAPK)/JNK but can inhibit the activation of ERK1/2 induced by vascular endothelial growth factor (VEGF) in HUVEC cells [8].