pCagACT and/or pCagAFL were observed in infections with Hp isolates containing EPIYA-ABC, EPIYA-ABCC, EPIYA-ABCCC, EPIYA-AABC and EPIYA-AABD motifs, but not in CagA proteins harboring EPIYA-AB, EPIYA-BC, or EPIYA-ABD (Figure 2A, left panel), which likely reflect individual differences in Hp strains. The gene discussed is HP; the disease is infection.