Our studies indicated that, in progressive osteoporosis, FLL could inhibit oxidative stress by reducing MDA content and enhancing SOD activity; enrich bone nutrition by increasing the bone dry–wet ratio and bone index; improve bone microstructure by regulating bone mineral density, bone volume fraction, and calcium loss; and enhance osteogenesis by promoting cell proliferation and OPG protein expression of osteoblasts. This evidence concerns the gene TNFRSF11B and osteoporosis.