Ectopic overexpression of transcription factor EB (TFEB) in transgenic mice mitigated the expression of senescence markers including P16INK4a, lamin B1, or H2A histone family member X (γ-H2AX) in the hippocampus and cerebral cortex, suggesting anti-aging effects and pointing to TFEB as a possible therapeutic target to ameliorate cognitive decline [132]. This evidence concerns the gene H2AX and Mental deterioration.