The model selected as the best was made by a linear two-compartment model, describing the absorption from both the first and the second IP compartment (Model 3), coupled with a two-compartment model of insulin kinetics, similar to that included in the UVa/Padova T1D simulator [15], but with hepatic insulin extraction controlled by insulin in the liver (Model C). This evidence concerns the gene INS and type 1 diabetes mellitus.