Since aluminum acts as a cross-linker to a variety of proteins and forms neoantigens, our aim in this study was to examine immune response to aluminum hydroxide, aluminum citrate and aluminum potassium sulfate bound to human serum albumin (HSA) in sera obtained from blood donors (controls), patients with autoimmune diseases, and patients with a disorder unrelated to aluminum for contrast and control. The gene discussed is ALB; the disease is autoimmune disease.