We used ELISA plates coated with three different forms of aluminum bound to HSA to measure the presence of aluminum-specific IgG antibody in sera obtained from blood donors and patients who were ASCA-positive, patients who were α-gliadin- and tTG-positive, patients who were ANA-positive, and patients who were positive for Alzheimer’s disease. This evidence concerns the gene BTG3 and early-onset autosomal dominant Alzheimer disease.