Compared to blood donors, we detected high levels of IgG antibody against the different aluminum-HSA complexes foremost in samples from patients who were ASCA IgA-positive (an indication of Crohn’s disease), and also in the samples from patients who were positive for α-gliadin-33 mer and tTG IgA (an indication of celiac disease). This evidence concerns the gene TGM2 and celiac disease.