Related to the panorama of risk factors for COVID-19, an imbalance between extracellular HSP70 (eHSP70) and intracellular HSP70 (iHSP70) which is counteracted by exercise, has been proposed to play a role in type 2 diabetes, with eHSP being more pro-inflammatory and iHSP70 more anti-inflammatory and associated with better insulin sensitivity [312] (Figure 4). Here, INS is linked to COVID-19.