MBNL1 and cancer: An important consequence is that splicing defects that characterize many human diseases such as cancers or the Myotonic Dystrophy type 1 (DM1), caused by a toxic RNA-based sequestration of the splicing factor Muscleblind Like Splicing Regulator 1 (MBNL1), may have a much broader impact than just affecting the production of proteins [12].