POMC and pituitary gland adenoma: Subsequently, they demonstrated that TPS-1 overexpression in the murine AtT20 corticotroph tumor cell line resulted in a decrease both of corticotroph precursor hormone proopiomelanocortin (POMC) synthesis and secretion of adrenocorticotropic hormone (ACTH), and suppressed pituitary adenoma cell proliferation, migration, and invasion.