Based on previous studies, in which differential expression of miR-145, miR-21, miR-141, let-7a, miR-150, miR-15a, miR-16, and miR-143 was observed in ACTH-secreting pituitary tumors compared to healthy pituitary tissues [94], Belaya et al. [101] assessed their expression profile in the plasma of patients affected by ACTH-dependent CS caused by either EAS or CD. The gene discussed is POMC; the disease is Cowden syndrome 1.