In addition, this study reveals that histone citrullination induced by PADs downregulate the expression profiles of three tumor suppressor miRNAs (let-7c-2, miR-23b, and miR-29c), which are predicted to directly target oncogenes involved in somatoprolactinomas and prolactinomas pathogenesis, such as insulin-like growth factor 1 (IGF-1), HMGA1, and N-MYC. This evidence concerns the gene IGF1 and neoplasm.