Regarding MEN1-associated PAs, Lines KE et al. [92] studied the levels of three miRNAs, miR-16-1, miR-15a, and let-7a, demonstrated to be downregulated in different subtypes of non-MEN1 PAs [16,93,94,95,96,97], in pituitary neoplasms from heterozygous MEN1 mutant mice (MEN1+/− mice). The gene discussed is MEN1; the disease is pituitary tumor.