TNS1 and COVID-19: However, miR-31-5p, has also been implicated in activity that would ordinarily be protective in COVID-19, as one study predicted one of its targets to be Tensin-1 (TNS1), a contributory factor to enhanced immune cell infiltration [23], associating miR-31-5p upregulation with TNS1 downregulation in patients with colon adenocarcinoma.